Attribution: Please use this identifier to share, cite, or link to this item: http://hdl.handle.net/10625/50228
Title: Retrocyclin 2 : a new therapy against avian influenza H5N1 virus in vivo and vitro
Authors: Qing-long Liang
Kai Zhou
Hong-xuan He
Keywords: AVIAN INFLUENZA VIRUS
CHICKEN EMBRYOS
H5N1 VIRUS
INFLUENZA VIRUS
MDCK CELLS
RETROCYCLIN 2
INFLUENZA IN BIRDS
INFLUENZA A VIRUS, H5N1 SUBTYPE
Date: 2010
Publisher: Springer
Citation: Qing-long Liang, Kai Zhou, & Hong-xuan He (2010). Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro. Biotechnol Lett, 32, 387-392. doi:10.1007/s10529-009-0167-2
Abstract: We tested the ability of retrocyclin 2, a type of h defensin, to protect cells and chicken embryos from infection by H5N1 highly pathogenic avian influenza virus. A gene fragment of retrocyclin 2 was designed based on the protein sequence of retrocyclin 2 and cloned into the eukaryotic expression vector pcDNA4.01 (HismaxA), named pcDNA4-RC2. The expression vector pcDNA4-RC2 protected MDCK cells and chicken embryos from infection by the H5N1 virus through inhibition of virus replication and viral mRNA transcription. Retrocyclin 2 is therefore effective in preventing H5N1 virus infection in vivo and in vitro and could be considered as a new therapy for H5N1 influenza and other diseases.
URI: http://hdl.handle.net/10625/50228
Project Number: 103190
Project Title: Avian Influenza in Migratory Birds : Regional Surveillance and Monitoring Network
Access: IDRC Only
Copyright: Springer Science+Business Media B.V.
Access Restriction: Due to copyright restrictions the full text of this research output is not available in the IDRC Digital Library or by request from the IDRC Library. / Compte tenu des restrictions relatives au droit d`auteur, le texte intégral de cet extrant de recherche n`est pas accessible dans la Bibliothèque numérique du CRDI, et il n`est pas possible d`en faire la demande à la Bibliothèque du CRDI.
Files in This Item:
There are no files associated with this item.
Show full item record