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Please use this identifier to cite or link to this item: http://hdl.handle.net/10625/50228

Title: Retrocyclin 2 : a new therapy against avian influenza H5N1 virus in vivo and vitro
Authors: Qing-long Liang
Kai Zhou
Hong-xuan He
Keywords: AVIAN INFLUENZA VIRUS
CHICKEN EMBRYOS
H5N1 VIRUS
INFLUENZA VIRUS
MDCK CELLS
RETROCYCLIN 2
INFLUENZA IN BIRDS
INFLUENZA A VIRUS, H5N1 SUBTYPE
Issue Date: 2010
Publisher: Springer
Citation: Qing-long Liang, Kai Zhou, & Hong-xuan He (2010). Retrocyclin 2: a new therapy against avian influenza H5N1 virus in vivo and vitro. Biotechnol Lett, 32, 387-392. doi:10.1007/s10529-009-0167-2
Abstract: We tested the ability of retrocyclin 2, a type of h defensin, to protect cells and chicken embryos from infection by H5N1 highly pathogenic avian influenza virus. A gene fragment of retrocyclin 2 was designed based on the protein sequence of retrocyclin 2 and cloned into the eukaryotic expression vector pcDNA4.01 (HismaxA), named pcDNA4-RC2. The expression vector pcDNA4-RC2 protected MDCK cells and chicken embryos from infection by the H5N1 virus through inhibition of virus replication and viral mRNA transcription. Retrocyclin 2 is therefore effective in preventing H5N1 virus infection in vivo and in vitro and could be considered as a new therapy for H5N1 influenza and other diseases.
URI: http://hdl.handle.net/10625/50228
Project Number: 103190
Project Title: Avian Influenza in Migratory Birds : Regional Surveillance and Monitoring Network
Document Delivery: This document is not available in the IDRC Digital Library / Ce document n'est pas disponible dans la Bibliothèque numérique du CRDI
Appears in Collections:IDRC Research Results / Résultats de recherches du CRDI
2010-2019 / Années 2010-2019
Research Results (Ecohealth) / Résultats de recherches (Écosanté)

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