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Title: New insights into gill epithelial transport: Linking ammonia excretion and sodium uptake
Authors: Wright, P A
Wood, C M
Cooper, C A
Keywords: AMMONIA
Date: 2011
Citation: Wright, P. A., Wood, C. M., & Cooper, C. A. (2011). New insights into gill epithelial transport: Linking ammonia excretion and sodium uptake. Proceedings of the 8th International Congress of Comparative Physiology and Biochemistry.
Abstract: Models of gill epithelial transport are rapidly changing as researchers discover more complex and specialized cell types and use genomic data to uncover completely new protein transporters. Maetz and Garcia Romeu (1964) first suggested a linkage between ammonia excretion and active Na+ uptake at the gills of freshwater animals. Although many studies have provided supporting evidence for such a linkage, only in the last 4 years with the discovery of ammonia-transporting Rhesus (Rh) glycoproteins in gill tissue have we been able to more fully understand the model of gill ammonia transport in freshwater animals. Recent evidence supports an apical “Na+/NH4 + exchange complex” consisting of several membrane transporters (Rhcg, V type H+ATPase, Na+/H+ exchanger (NHE 2/3, Na+ channel) working together as a metabolon providing an acid-trapping mechanism for apical excretion in freshwater fish. The model for gill ammonia transport in seawater is more controversial, although Rhcg also appears to be associated with Na+ transport.
Project Number: 104519
Project Title: International Research Chairs Initiative (IRCI)
Access Restriction: Due to copyright restrictions the full text of this research output is not available in the IDRC Digital Library or by request from the IDRC Library. / Compte tenu des restrictions relatives au droit d`auteur, le texte intégral de cet extrant de recherche n`est pas accessible dans la Bibliothèque numérique du CRDI, et il n`est pas possible d`en faire la demande à la Bibliothèque du CRDI.
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