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Please use this identifier to cite or link to this item: http://hdl.handle.net/10625/48010

Title: Disability weight of Clonorchis sinensis infection : captured from community study and model simulation
Authors: Men-Bao Qian
Ying-Dan Chen
Yue-Yi Fang
Long-Qi Xu
Ting-Jun Zhu
Keywords: CLONORCHIS SINENSIS
CLONORCHIASIS
DISABILITY WEIGHT
DISEASE BURDEN
TROPICAL DISEASES
Issue Date: 2011
Publisher: Public Library of Science
Citation: Qian, M., Chen, Y., Fang, Y., Xu, L., Zhu, T., Tan, T., … Zhou, X. (2011). Disability weight of Clonorchis sinensis infection : captured from community study and model simulation. PLoS Negl Trop Dis, 5(12): e1377. doi:10.1371/journal.pntd.0001377
Abstract: Background: Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disabilityadjusted life years (DALYs). Methodology/Principal Findings: According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5–14, 15–29, 30–44, 45–59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation. Conclusion/Significance: The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection.
URI: http://hdl.handle.net/10625/48010
Project Number: 105509
Project Title: Ecohealth Emerging Infectious Diseases Research Initiative (EcoEID)
Appears in Collections:IDRC Research Results / Résultats de recherches du CRDI
Research Results (Ecohealth) / Résultats de recherches (Écosanté)
Research Results (GHRI) / Résultats de recherches (IRSM)
Ecohealth Emerging Infectious Diseases Research Initiative (EcoEID) / écosanté sur les maladies infectueuses émergentes (écoMIE)
Health Systems Research / recherche sur les systèmes de santé
2010-2019 / Années 2010-2019

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