http://idl-bnc.idrc.ca:80/dspace/handle/10625/49645 Wed, 19 Jun 2013 15:11:07 GMT 2013-06-19T15:11:07Z http://idl-bnc.idrc.ca:80/dspace/handle/10625/49956 Title: The current status of opisthorchiasis in the Mekong Basin Authors: Sithithaworn, P; Andrews, R H; Van De, N; Wongsaroj, T; Sinuon, M Abstract: This review highlights the current status and control of liver fluke infections in the Mekong Basin countries where Opisthorchis and Clonorchis are highly endemic. Updated data on prevalence and distribution have been summarized from presentations in the “96 Years of Opisthorchiasis. International Congress of Liver Flukes”. It is disturbing that despite treatment and control programs have been in place for decades, all countries of the Lower Mekong Basin are still highly endemic with O. viverrini and/or C. sinensis as well as alarmingly high levels of CCA incidence. A common pattern that is emerging in each country is the difference in transmission of O. viverrini between lowlands which have high prevalence versus highlands which have low prevalence. This seems to be associated with wetlands, flooding patterns and human movement and settlement. A more concerted effort from all community, educational, public health and government sectors is necessary to successfully combat this fatal liver disease of the poor. Sat, 01 Jan 2011 00:00:00 GMT http://idl-bnc.idrc.ca:80/dspace/handle/10625/49956 2011-01-01T00:00:00Z http://idl-bnc.idrc.ca:80/dspace/handle/10625/48010 Title: Disability weight of Clonorchis sinensis infection : captured from community study and model simulation Authors: Men-Bao Qian; Ying-Dan Chen; Yue-Yi Fang; Long-Qi Xu; Ting-Jun Zhu Abstract: Background: Clonorchiasis is among the most neglected tropical diseases. It is caused by ingesting raw or undercooked fish or shrimp containing the larval of Clonorchis sinensis and mainly endemic in Southeast Asia including China, Korea and Vietnam. The global estimations for population at risk and infected are 601 million and 35 million, respectively. However, it is still not listed among the Global Burden of Disease (GBD) and no disability weight is available for it. Disability weight reflects the average degree of loss of life value due to certain chronic disease condition and ranges between 0 (complete health) and 1 (death). It is crucial parameter for calculating the morbidity part of any disease burden in terms of disabilityadjusted life years (DALYs). Methodology/Principal Findings: According to the probability and disability weight of single sequelae caused by C. sinensis infection, the overall disability weight could be captured through Monte Carlo simulation. The probability of single sequelae was gained from one community investigation, while the corresponding disability weight was searched from the literatures in evidence-based approach. The overall disability weights of the male and female were 0.101 and 0.050, respectively. The overall disability weights of the age group of 5–14, 15–29, 30–44, 45–59 and 60+ were 0.022, 0.052, 0.072, 0.094 and 0.118, respectively. There was some evidence showing that the disability weight and geometric mean of eggs per gram of feces (GMEPG) fitted a logarithmic equation. Conclusion/Significance: The overall disability weights of C. sinensis infection are differential in different sex and age groups. The disability weight captured here may be referred for estimating the disease burden of C. sinensis infection. Sat, 01 Jan 2011 00:00:00 GMT http://idl-bnc.idrc.ca:80/dspace/handle/10625/48010 2011-01-01T00:00:00Z